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SSE1806

CAT: 0804-HY-156088-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156088-01Size:1 mg
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Description
SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1[1].
CAS Number
3053861-26-7
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sse1806.html
Solubility
10 mM in DMSO
Smiles
O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
References & Citations
[1]Firdous F, et al. Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance[J]. ACS Medicinal Chemistry Letters, 2023...
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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