HMGB1-IN-2

CAT: 0804-HY-155759Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155759Size:1 Each

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Description

HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC50 value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC50s of 77.0 μM, and 82.0 μM, respectively[1].

UNSPSC

12352005

Target

Apoptosis; Caspase; Interleukin Related; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hmgb1-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C=C1[C@@]2([C@@](CC[C@@]31C)(CC[C@@](C)(C2)C(OCC4=CN([C@@H]5O[C@H](C)[C@@H](OC(C)=O)[C@H](OC(C)=O)C5)N=N4)=O)C)[H])[C@@]6([C@@](CC[C@@H](C7(C)C)OC(/C=C/C8=CC=C(OC)C=C8)=O)(C7CC[C@@]36C)C)[H]

Molecular Formula

C53H71N3O11

Molecular Weight

926.14

References & Citations

[1]Qiang X, et al. Synthesis of glycyrrhizin analogues as HMGB1 inhibitors and their activity against sepsis in acute kidney injury. Eur J Med Chem. 2023 Nov 5;259:115696.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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