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Antiviral agent 35

CAT: 0804-HY-155731Size: 1 EachDry Ice: NoHazardous: No
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Description
Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM[1].
CAS Number
2760972-52-7
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antiviral-agent-35.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC=C(C=C1)S(=O)(N(C2=CC=CC3=C2C=CC=C3)CC4=CC=CC=C4)=O)[O-]
Molecular Formula
C23H18N2O4S
Molecular Weight
418.47
References & Citations
[1]Ge Y, et al. Synthesis and pharmacodynamic evaluation of naphthalene derivatives against influenza A virus in vitro and in vivo. Eur J Med Chem. 2023 Nov 5;259:115660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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