HMG-CoA Reductase-IN-1

• UNSPSC Description:

  HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC50 and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia[1].

• Target Antigen:

  HMG-CoA Reductase (HMGCR)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/hmg-coa-reductase-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C=C1)NC(C2=C(/C=C/[C@H](C[C@@H](O)CC(O)=O)O)C(C(C)C)=NC(C3=CC=C(C=C3)O)=N2)=O

• Molecular Weight:

  507.54

• References & Citations:

  [1]Samizo S, et al. Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors. ACS Omega. 2023 Jul 18;8(30):27247-27255.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported