KSK68

CAT: 0804-HY-155614-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-155614-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain[1].

CAS Number

2566715-91-9

UNSPSC

12352005

Target

Histamine Receptor; Sigma Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ksk68.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CC1)C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2

Molecular Formula

C23H28N2O2

Molecular Weight

364.48

References & Citations

[1]Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66 (14) :9658-9683.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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