ZG36

CAT: 0804-HY-155556Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155556Size:1 Each

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Description

ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model[1].

CAS Number

2999673-34-4

UNSPSC

12352005

Target

ClpP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zg36.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(CNC(N(CC2)[C@]3([H])N([C@H](C(N(C3)CC4=C5C(C=CC=C5)=C(OC)C=C4)=O)[C@H](CC)C)C2=O)=O)C=C1

Molecular Formula

C31H35BrN4O4

Molecular Weight

607.54

References & Citations

[1]Zhang R, et al. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists. Eur J Med Chem. 2023 Oct 5;258:115577.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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