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IRAK4-IN-26

CAT: 0804-HY-155519Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155519Size:1 Each
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Description
IRAK4-IN-26 (Compound 21) is a IRAK4 inhibitor (IC50: 6.2 nM) . IRAK4-IN-26 displays an oral bioavailability of 21%. IRAK4-IN-26 can be used for research of inflammatory and autoimmune disorders[1].
CAS Number
2952533-49-0
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-26.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=CN(C)N=C2)=N1)C(C(OC3CC3)=N4)=CC5=C4OC(C)(C)C5
Molecular Formula
C22H23N5O3
Molecular Weight
405.45
References & Citations
[1]Hao Y, et al. Synthesis and evaluation of dihydrofuro[2,3-b]pyridine derivatives as potent IRAK4 inhibitors. Eur J Med Chem. 2023 Oct 5;258:115616.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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