PRO-HD1

CAT: 0804-HY-155396Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155396Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC50: 5.8 μM) [1].

UNSPSC

12352005

Target

HDAC; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pro-hd1.html

Solubility

10 mM in DMSO

Smiles

S=C1N(CC2=CC=C(C3=CC=C(CNCCCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)C=C2)C=CC=C1O

Molecular Formula

C36H35N5O5S

Molecular Weight

649.76

References & Citations

[1]Jia Q, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Anal Chem. 2023 Oct 30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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