SARS-CoV-2-IN-60

SARS-CoV-2-IN-60

• UNSPSC Description: SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 μM and a Ki of 26 μM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-in-60.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(/C=C/C2=NC(O)=NC(C(F)(F)F)=C2)C(Cl)=C1
• Molecular Weight: 335.11
• References & Citations: [1]Nicole L Inniss, et al. Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors. ACS Infect Dis. 2023 Oct 13;9(10):1918-1931.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported