Pomalidomide-5-C4-NH2 (hydrochloride)

Pomalidomide-5-C4-NH2 (hydrochloride)

• UNSPSC Description: Pomalidomide-5-C4-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pomalidomide-5-c4-nh2-hydrochloride.html
• Purity: 98.45
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(C=CC(NCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
• Molecular Weight: 380.83
• References & Citations: [1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported