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IRAK4-IN-28

CAT: 0804-HY-155132Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155132Size:1 Each
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Description
IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM) . IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].
CAS Number
2952532-92-0
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-28.html
Solubility
10 mM in DMSO
Smiles
CN1N=CC(C2=CC=CC(NC(C3=CC(O4)=C(N=C3N5CCN(C6CC6)CC5)N=C4N7CCOCC7)=O)=N2)=C1
Molecular Formula
C27H31N9O3
Molecular Weight
529.59
References & Citations
[1]Yongjin Hao, et al. Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorg Chem. 2023 , 137:106584.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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