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SMA4

CAT: 0804-HY-155106-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155106-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMA4 is a selective PKG1α activator with basal EC50 value of 29 μM. SMA4 facilitates phosphorylation of the known PKG1 substrate, vasodilator-stimulated phosphoprotein (VASP), and inhibits human pulmonary arterial smooth muscle cells (hPASMC) proliferation. SMA4 can be used for cardiovascular disease research[1].
UNSPSC
12352005
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sma4.html
Purity
98.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@]1(C2=CC=CC=C2)[C@](O[C@@H](CO)C3=CC(Cl)=CC(Cl)=C3)([H])CCCN1CC4=NC5=C(N4)C=CC(C(O)=O)=C5
Molecular Formula
C28H27Cl2N3O4
Molecular Weight
540.44
References & Citations
[1]Metwally E, et al. Structural insights into selective small molecule activation of PKG1α. Commun Biol. 2023 Jul 31;6 (1) :798.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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