SMA4

• Description :

  SMA4 is a selective PKG1α activator with basal EC50 value of 29 μM. SMA4 facilitates phosphorylation of the known PKG1 substrate, vasodilator-stimulated phosphoprotein (VASP), and inhibits human pulmonary arterial smooth muscle cells (hPASMC) proliferation. SMA4 can be used for cardiovascular disease research[1].

• UNSPSC :

  12352005

• Target :

  PKG

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/sma4.html

• Purity :

  98.52

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  [H][C@]1(C2=CC=CC=C2)[C@](O[C@@H](CO)C3=CC(Cl)=CC(Cl)=C3)([H])CCCN1CC4=NC5=C(N4)C=CC(C(O)=O)=C5

• Molecular Formula :

  C28H27Cl2N3O4

• Molecular Weight :

  540.44

• References & Citations :

  [1]Metwally E, et al. Structural insights into selective small molecule activation of PKG1α. Commun Biol. 2023 Jul 31;6 (1) :798.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported