SMA-12b

• UNSPSC Description:

  SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases[1].

• Target Antigen:

  Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Others

• Assay Protocol:

  https://www.medchemexpress.com/sma-12b.html

• Smiles:

  O=S(CC[N+](C)(C)C)(CC1=CC=C(C=C1)C)=O.[I-]

• Molecular Weight:

  383.29

• References & Citations:

  [1]Rzepecka J, et al. Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome[J]. Journal of autoimmunity, 2015, 60: 59-73.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1496553-39-9