5-(2-Hydroxyethyl)cytidine

• UNSPSC Description:

  5-(2-Hydroxyethyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/5-2-hydroxyethyl-cytidine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=C(CCO)C(N)=NC2=O

• Molecular Weight:

  287.27

• References & Citations:

  [1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  137248-64-7