DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite

DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite

• CAS Number: 325683-97-4
• UNSPSC Description: DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dmtr-tna-g-o6-conph2-n2ac-amidite.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)N(C(C)C)P(O[C@@H]1[C@@H](OC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CO[C@H]1N(C=N5)C6=C5C(OC(N(C7=CC=CC=C7)C8=CC=CC=C8)=O)=NC(NC(C)=O)=N6)OCCC#N
• Molecular Weight: 993.05
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported