5'-ODMT cEt G Phosphoramidite (Amidite)

5'-ODMT cEt G Phosphoramidite (Amidite)

• CAS Number: 945628-66-0
• UNSPSC Description: 5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity[1][2].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/5-odmt-cet-g-phosphoramidite-amidite.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C3=C(C(N=C(N3)NC(C(C)C)=O)=O)N=C2)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC
• Molecular Weight: 881.95
• References & Citations: [1]Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.|[2]Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported