5-Azidomethyl-2’-beta-methyl-2’,3’,5’-tri-O-benzoyluridine

5-Azidomethyl-2’-beta-methyl-2’,3’,5’-tri-O-benzoyluridine

• CAS Number: 2305416-08-2
• UNSPSC Description: 5-Azidomethyl-2’-beta-methyl-2’,3’,5’-tri-O-benzoyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. 5-Azidomethyl-2’-beta-methyl-2’,3’,5’-tri-O-benzoyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5-azidomethyl-2-beta-methyl-2-3-5-tri-o-benzoyluridine.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC(C(CN=[N+]=[N-])=C1)=O)N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)=O)[C@@H](OC(C4=CC=CC=C4)=O)[C@@]2(C)OC(C5=CC=CC=C5)=O
• Molecular Weight: 625.58
• References & Citations: [1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported