5-(Azidomethyl)-2’-O-(2-methoxyethyl)uridine

5-(Azidomethyl)-2’-O-(2-methoxyethyl)uridine

• CAS Number: 2305415-77-2
• UNSPSC Description: 5-(Azidomethyl)-2’-O-(2-methoxyethyl)uridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. 5-(Azidomethyl)-2’-O-(2-methoxyethyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/5-azidomethyl-2-o-2-methoxyethyl-uridine.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@@H]1[C@H](OCCOC)[C@H](N2C(C(CN=[N+]=[N-])C(N=C2)=O)=O)O[C@@H]1CO
• Molecular Weight: 357.32
• References & Citations: [1]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported