2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine

• UNSPSC Description:

  2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-azido-2-deoxy-5-o-4-4-dimethoxytrityl-5-methyluridine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](N=[N+]=[N-])[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5

• Molecular Weight:

  585.61

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2095417-08-4