2′-Azido-2′-deoxy-5-methyluridine

• UNSPSC Description:

  2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-2′-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-azido-2-deoxy-5-methyluridine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@@H]1[C@@H](O)[C@@H](N=[N+]=[N-])[C@H](N2C(NC(C(C)=C2)=O)=O)O1

• Molecular Weight:

  283.24

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  97748-75-9