2’,3’-Isopropylidene-5-hydroxyuridine

• UNSPSC Description:

  2’,3’-Isopropylidene-5-hydroxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-3-isopropylidene-5-hydroxyuridine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(O)=CN1[C@H]2[C@H](OC(C)(C)O3)[C@H]3[C@@H](CO)O2)NC1=O

• Molecular Weight:

  300.26

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  20406-82-0