3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine

• UNSPSC Description:

  3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Oligonucleotides

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/3-o-4-4-dimethoxy-trityl-2-o-2-methoxyethyl-5-methyluridine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC[C@H]([C@@H](OC(C1=CC=CC=C1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)[C@H]4OCCOC)O[C@H]4N5C(NC(C(C)=C5)=O)=O

• Molecular Weight:

  618.67

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported