3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine

3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine

• UNSPSC Description: 3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/3-5-bis-o-t-butyldimethylsilyl-2-o-methyl-5-methyl-cytidine.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CN(C(N=C1N)=O)[C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]2OC
• Molecular Weight: 499.79
• References & Citations: [1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported