DG-8

• Description :

  DG-8 is a potent inhibitor of STAT3-dependent transcription (IC50 0.98 μM) . DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety[1].

• UNSPSC :

  12171500

• Target :

  Fluorescent Dye; STAT

• Type :

  Dye Reagents

• Related Pathways :

  JAK/STAT Signaling; Others; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/dg-8.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N(CCN(C)S(C1=C(C=CC=C2N(C)C)C2=CC=C1)(=O)=O)C)C3=CC=C(N4C(C(Cl)=C(Cl)C=N4)=O)C=C3.Cl

• Molecular Formula :

  C27H28Cl3N5O4S

• Molecular Weight :

  624.97

• References & Citations :

  [1]Busker S, et al. Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death. Sci Adv. 2020 Mar 20;6 (12) :eaax7945.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported