DG-8

• UNSPSC Description:

  DG-8 is a potent inhibitor of STAT3-dependent transcription (IC50 0.98 μM). DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety[1].

• Target Antigen:

  Fluorescent Dye; STAT

• Type:

  Dye Reagents

• Related Pathways:

  JAK/STAT Signaling;Others;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/dg-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(CCN(C)S(C1=C(C=CC=C2N(C)C)C2=CC=C1)(=O)=O)C)C3=CC=C(N4C(C(Cl)=C(Cl)C=N4)=O)C=C3.Cl

• Molecular Weight:

  624.97

• References & Citations:

  [1]Busker S, et al. Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death. Sci Adv. 2020 Mar 20;6(12):eaax7945.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported