DG-041

• Description:

  DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier[1][2].

• UNSPSC:

  12352005

• Target:

  Prostaglandin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/dg-041.html

• Purity:

  99.61

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C (NS (=O) (C1=CC (Cl) =C (Cl) S1) =O) /C=C/C2=CC (F) =CC3=C2N (CC4=CC=C (Cl) C=C4Cl) C=C3C

• Molecular Formula:

  C23H15Cl4FN2O3S2

• Molecular Weight:

  592.32

• References & Citations:

  [1]Singh J, et al. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem Biol. 2009 Feb 20;4 (2) :115-26.|[2]Hategan G, et al. Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptorantagonists. Bioorg Med Chem Lett. 2009 Dec 1;19 (23) :6797-800.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  EP

• CAS Number:

  861238-35-9