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FEN1-IN-6

CAT: 0804-HY-153791Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153791Size:1 Each
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Description
FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM[1].
CAS Number
824983-84-8
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fen1-in-6.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C(N1O)=O)SC=C2S(=O)(C3=CC=CC=C3)=O
Molecular Formula
C12H8N2O5S2
Molecular Weight
324.33
References & Citations
[1]Tumey LN, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15 (2) :277-81.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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