FEN1-IN-3

CAT: 0804-HY-136484-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-136484-01Size:5 mg

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Description

FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM[1].

CAS Number

2109805-87-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

FLAP

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fen1-in-3.html

Concentration

10mM

Purity

98.06

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N1O)N(C2=CC=C(OC)C=C2)C3=C(C=CC=C3)C1=O

Molecular Formula

C15H12N2O4

Molecular Weight

284.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12 (10) :815-21.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Fen1-IN-3

CAS Number	2109805-87-8
PubChem CID	132585224
IUPAC Name	3-hydroxy-1-(4-methoxyphenyl)quinazoline-2,4-dione
Molecular Formula	C15H12N2O4
Molecular Weight	284.27
XLogP	1.8
Topological Polar Surface Area	70.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	21
Formal Charge	0
Complexity	420

SMILES

COC1=CC=C(C=C1)N2C3=CC=CC=C3C(=O)N(C2=O)O

InChI

InChI=1S/C15H12N2O4/c1-21-11-8-6-10(7-9-11)16-13-5-3-2-4-12(13)14(18)17(20)15(16)19/h2-9,20H,1H3

InChIKey

BBJIIPZSHQTBLW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2109805-87-8

CID: 132585224

Formula: C15H12N2O4

MW: 284.27

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	284.27
XLogP3	1.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	284.07970687
Monoisotopic Mass	284.07970687
Topological Polar Surface Area	70.1 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	420
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-153791	FEN1-IN-6
HY-123834-01	FEN1-IN-1
HY-175883	FEN1-IN-8
HY-153792	FEN1-IN-7
HY-136485-01	FEN1-IN-4
HY-122695-01	FEN1-IN-2
HY-145758-01	FEN1-IN-SC13
HY-153790-01	FEN1-IN-5
HY-P80669-01	FEN1 Antibody (YA765, Mouse)
HY-P85603	FEN1 Antibody (YA5295, Mouse)

Alternative Products

Catalog	Name
BA5972-5	FEN1-IN-3
enz-468	FEN1
GTR17978042	FEN1 Antibody
BA5973-5	FEN1-IN-2
BA4090-25	FEN1-IN-SC13

FEN1-IN-3

Chemical Information

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