JAK-IN-27

JAK-IN-27

• CAS Number: 2673176-36-6
• UNSPSC Description: JAK-IN-27 (Compound 1) is a JAK inhibitor. JAK-IN-27 inhibits TYK2, JAK1, JAK2 with IC50s of 3.0, 7.7, 8.5 nM respectively. JAK-IN-27 inhibits IFN-α2b induced p-STAT3 in Jurkat cells (IC50: 23.7 nM)[1].
• Target Antigen: JAK
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/jak-in-27.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H](C1)C1(F)F)N2[C@H]3CN(C[C@@H]2CC3)C4=NC(C(C=N5)=CN5C)=CN6C4=CC=N6
• Molecular Weight: 413.42
• References & Citations: [1]Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.|[2]Zhang Panpan. Pyrazolo [1,5-a ] pyrazine derivative and preparation method and application thereof. Patent. CN113150012.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported