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JAK-IN-27

CAT: 0804-HY-153702Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153702Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK-IN-27 (Compound 1) is a JAK inhibitor. JAK-IN-27 inhibits TYK2, JAK1, JAK2 with IC50s of 3.0, 7.7, 8.5 nM respectively. JAK-IN-27 inhibits IFN-α2b induced p-STAT3 in Jurkat cells (IC50: 23.7 nM) [1].
CAS Number
2673176-36-6
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak-in-27.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](C1)C1(F)F)N2[C@H]3CN(C[C@@H]2CC3)C4=NC(C(C=N5)=CN5C)=CN6C4=CC=N6
Molecular Formula
C20H21F2N7O
Molecular Weight
413.42
References & Citations
[1]Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.|[2]Zhang Panpan. Pyrazolo [1,5-a ] pyrazine derivative and preparation method and application thereof. Patent. CN113150012.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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