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AP-C1

CAT: 0804-HY-153537Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153537Size:1 Each
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Description
AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP) -dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion[1].
CAS Number
2234280-26-1
UNSPSC
12352005
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ap-c1.html
Solubility
10 mM in DMSO
Smiles
COC(C(OC)=C1)=CC=C1CCNC2=NC=CC(C3=CC4=C(C=CC=C4)C=C3)=N2
Molecular Formula
C24H23N3O2
Molecular Weight
385.46
References & Citations
[1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293 (21) :8173-8181.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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