AP-C1

• Description:

  AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP) -dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion[1].

• UNSPSC:

  12352005

• Target:

  PKG

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ap-c1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC (C (OC) =C1) =CC=C1CCNC2=NC=CC (C3=CC4=C (C=CC=C4) C=C3) =N2

• Molecular Formula:

  C24H23N3O2

• Molecular Weight:

  385.46

• References & Citations:

  [1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293 (21) :8173-8181.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2234280-26-1