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Faldaprevir

CAT: 0804-HY-15256Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15256Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Faldaprevir (BI 201335) is a potent, orally active and selective noncovalent inhibitor of NS3/4A protease of HCV (hepatitis C virus) genotypes 1a and 1b, with Ki values of 2.6 and 2.0 nM, respectively. Faldaprevir inhibits HCV RNA replication, with EC50 values of 6.5 and 3.1 nM, respectively. Faldaprevir has potent antiviral activity against chronic HCV infection[1][2].
CAS Number
801283-95-4
Product Name Alternative
BI 201335
UNSPSC
12352005
Hazard Statement
H302
Target
HCV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/faldaprevir.html
Purity
98.58
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C([C@H](C[C@H]1OC2=CC(C3=CSC(NC(C(C)C)=O)=N3)=NC4=C2C=CC(OC)=C4Br)N(C1)C([C@H](C(C)(C)C)NC(OC5CCCC5)=O)=O)N[C@@]([C@@H]6C=C)(C6)C(O)=O
Molecular Formula
C40H49BrN6O9S
Molecular Weight
869.82
Precautions
H302
References & Citations
[1]Llinàs-Brunet M, et al. Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335) . J Med Chem. 2010 Sep 9;53 (17) :6466-76.|[2]Zeuzem S, et al. Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results. Antivir Ther. 2013;18 (8) :1015-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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