MenA-IN-1

• Description :

  MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC50 value of 13 µM and an GIC50 value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mena-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCN(C1=CC=C(C=C1)CN2CCC(CC2)COC3=CC(OC4=CC=CC=C4)=CC=C3)C

• Molecular Formula :

  C29H36N2O2

• Molecular Weight :

  444.61

• References & Citations :

  [1]Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023 Jan 18;249:115125.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported