DDO3711

CAT: 0804-HY-152247Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-152247Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 (ASK1) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 (IC50 =164.1 nM) not ASK2 (IC50>20 μM) . DDO3711 significantly dephosphorylates p-ASK1T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research[1].

CAS Number

2673364-10-6

UNSPSC

12352005

Target

MAP3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ddo3711.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1OC)C2=NC(CC3=CC=C(C=C3)C(NCCCCCCNC(C4=CC=C(C=C4)C(NC5=CN6C=C(C=CC6=N5)N7C=CN=C7)=O)=O)=O)=NO2

Molecular Formula

C42H41N9O6

Molecular Weight

767.83

References & Citations

[1]Qiuyue Zhang, et al. Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity. J Am Chem Soc. 2022 Dec 22.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP3K6/ASK2

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GTR19212087-01	DDO3711

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