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DDO3711

CAT: 0931-T73460-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73460-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2673364-10-6
Target
MAPK, Others
Related Pathways
MAPK, Others
Bioactivity
DDO3711, a PP5-recruiting phosphatase recruitment chimera (PHORC), is created by chemically linking an apoptosis signal-regulated kinase 1 (ASK1) inhibitor with a PP5 activator. This compound selectively targets ASK1 (IC50=164.1 nM) over ASK2 (IC50 >20 μM), effectively dephosphorylating p-ASK1 T838 through PP5 recruitment. Exhibiting ASK1-dependent antiproliferative properties, DDO3711 demonstrates anti-cancer activity, making it a promising agent for research into the abnormal phosphorylation of oncoproteins.
Smiles
N(C(=O)C1=CC=C(C(NCCCCCCNC(=O)C2=CC=C(CC=3N=C(ON3)C4=CC(OC)=C(OC)C=C4)C=C2)=O)C=C1)C5=CN6C(=N5)C=CC(=C6)N7C=CN=C7
Molecular Formula
C42H41N9O6
Molecular Weight
767.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19212087-01DDO3711

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