KRAS G12C inhibitor 57
CAT:
804-HY-151968
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KRAS G12C inhibitor 57
- CAS Number: 2821863-70-9
- UNSPSC Description: KRAS G12C inhibitor 57 (Compound 50) is a potent, selective, covalent and orally active KRAS G12C inhibitor with an IC50 of 0.21 μM in KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell apoptosis[1].
- Target Antigen: Ras
- Type: Reference compound
- Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kras-g12c-inhibitor-57.html
- Solubility: 10 mM in DMSO
- Smiles: N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(N(C)C(C4=C5C(C)=CC=CC5=CC=C4)=C3)=NC(OC[C@@]67CCCN6C[C@H](F)C7)=N2)C1
- Molecular Weight: 607.72
- References & Citations: [1]Song Z, et al. Identification of novel Pyrrolo [2, 3-d] Pyrimidine-based KRAS G12C inhibitors with anticancer effects. European Journal of Medicinal Chemistry, 2022: 114907.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported