CPUL1

CAT: 0804-HY-151802Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-151802Size:1 Each

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Description

CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid or Dithiodipropionic acid (HY-W014395) is more effective[1].

CAS Number

2043660-80-4

UNSPSC

12352005

Target

TrxR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cpul1.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(OC2=C(C1C3=CC(Cl)=C(Cl)C=C3)C4=NC5=CC=CC=C5N=C4C=C2N)N

Molecular Formula

C22H13Cl2N5O

Molecular Weight

434.28

References & Citations

[1]Ding Q, et al. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production. Mol Biol Rep. 2022 Sep;49 (9) :8835-8845.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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