(S,R,S)-AHPC-C6-PEG3-butyl-N3

(S,R,S)-AHPC-C6-PEG3-butyl-N3

• CAS Number: 2300155-90-0
• UNSPSC Description: (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate[1]. (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker; E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-c6-peg3-butyl-n3.html
• Solubility: 10 mM in DMSO
• Smiles: [N-]=[N+]=NCCCCCCOCCOCCOCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O
• Molecular Weight: 757.98
• References & Citations: [1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported