Norbornene-methyl-NHS

CAT: 0804-HY-151742Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-151742Size:1 Each

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Description

Norbornene-methyl-NHS is a click chemistry reagent containing a TCO group. Dienophile for conjugation via Diels-Alder-reaction, i.e. copper-free click reaction with tetrazines[1].

CAS Number

1986791-87-0

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/norbornene-methyl-nhs.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC1CC2C=CC1C2)ON3C(CCC3=O)=O

Molecular Formula

C13H15NO5

Molecular Weight

265.26

References & Citations

[1]Selma Eising, et al. Vinylboronic Acids as Efficient Bioorthogonal Reactants for Tetrazine Labeling in Living Cells. Bioconjug Chem. 2018 Apr 18;29 (4) :982-986.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Norbornene-methyl-NHS

CAS Number	1986791-87-0
PubChem CID	102571744
IUPAC Name	2-bicyclo[2.2.1]hept-5-enylmethyl (2,5-dioxopyrrolidin-1-yl) carbonate
Molecular Formula	C13H15NO5
Molecular Weight	265.26
XLogP	1.3
Topological Polar Surface Area	72.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	19
Formal Charge	0
Complexity	442

SMILES

C1CC(=O)N(C1=O)OC(=O)OCC2CC3CC2C=C3

InChI

InChI=1S/C13H15NO5/c15-11-3-4-12(16)14(11)19-13(17)18-7-10-6-8-1-2-9(10)5-8/h1-2,8-10H,3-7H2

InChIKey

PYHZXEKPQIJFQY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1986791-87-0

CID: 102571744

Formula: C13H15NO5

MW: 265.26

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	265.26
XLogP3	1.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	265.09502258
Monoisotopic Mass	265.09502258
Topological Polar Surface Area	72.9 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	442
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	3
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Norbornene-methyl-NHS

Chemical Information

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