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PBRM1-BD2-IN-4

CAT: 0804-HY-151531Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151531Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBRM1-BD2-IN-4 (compound 15) is a potent PBRM1 Bromodomain inhibitor with Kd values of 5.5 μM and 11.1 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.2 μM for PBRM1-BD2. PBRM1-BD2-IN-4 can be used to research anticancer[1].
CAS Number
2819989-60-9
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbrm1-bd2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C2=CC=CC=C2C)NC3=C1C(Cl)=CC=C3
Molecular Formula
C15H13ClN2O
Molecular Weight
272.73
References & Citations
[1]Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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