Z164597606

CAT: 0804-HY-151405Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-151405Size:1 Each

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Description

Z164597606 is a selective BChE inhibitor (IC50: 1.3 and 1.7 μM for eqBChE and hBChE) . Z164597606 forms a π-π stacking interaction with the amino acid Trp82 of hBChE. Z164597606 can be used for the research of Alzheimer’s disease (AD) [1][2].

CAS Number

1050587-57-9

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z164597606.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC=C1)CN(CC2=CC=CC=C2[N+]([O-])=O)CC3=CC=CO3

Molecular Formula

C20H19N3O4

Molecular Weight

365.38

References & Citations

[1]Xin Lu, et al. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorg Chem. 2019 Apr;85:117-127. |[2]Xin Lu, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

BChE

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