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NHE3-IN-3

CAT: 0804-HY-151360Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151360Size:1 Each
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Description
NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].
CAS Number
543734-50-5
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nhe3-in-3.html
Solubility
10 mM in DMSO
Smiles
CN1CC2=C(C(C1)C3=CC(S(N)(=O)=O)=CC=C3)C=C(C=C2Cl)Cl
Molecular Formula
C16H16Cl2N2O2S
Molecular Weight
371.28
References & Citations
[1]Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13 (7) :1043-1051.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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