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TK4b

CAT: 0804-HY-151259Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151259Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK4b is a Janus kinase (JAK) inhibitor with the IC50 values of 19.40 nM and 18.42 nM for JAK2 and JAK3, respectively. TK4b can be used in lymphoid-derived diseases and leukemia cancer research[1].
CAS Number
2232890-81-0
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk4b.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=C(C)C(C)=C2)N(CC)C(C)=C1C(C3=CC=CC=C3)=O
Molecular Formula
C21H22N2O2
Molecular Weight
334.41
References & Citations
[1]Kamonpan Sanachai, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3

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