TK4g

CAT: 0804-HY-151258Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-151258Size:1 Each

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Description

TK4g is a Janus kinase (JAK) inhibitor with the IC50 values of 12.61 nM and 15.80 nM for JAK2 and JAK3, respectively. TK4g can be used in lymphoid-derived diseases and leukemia cancer research[1].

CAS Number

2232890-86-5

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tk4g.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=CC(N2N(CC)C(C)=C(C(C3=CC=CC=C3)=O)C2=O)=C1)(N)=O

Molecular Formula

C19H19N3O4S

Molecular Weight

385.44

References & Citations

[1]Kamonpan Sanachai, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega 2022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK2; JAK3

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