HDAC2-IN-1

HDAC2-IN-1

• CAS Number: 2919691-32-8
• UNSPSC Description: HDAC2-IN-1 (Compound 17) is a brain penetrant, orally active, competitive HDAC2 inhibitor with an IC50 of 0.5 μM[1]. HDAC2-IN-1 also inhibits HDAC1 and HDAC8 with IC50s of 1.61 μM and 0.98 μM, respectively[1].
• Target Antigen: HDAC
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/hdac2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC([C@@H]2C[C@H](C(N3CCN(CC3)C4=NC=CC5=C4SC=C5)=O)NC2)=CC=C1
• Molecular Weight: 426.96
• References & Citations: [1]Tamanini E, et al. Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. ACS Medicinal Chemistry Letters, 2022.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported