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HDAC4-IN-1

CAT: 0804-HY-149721Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149721Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC4-IN-1 (compound 1a) is a class IIa HDACI inhibitor (IC50=0.077 μM) . HDAC4-IN-1 can enhance Caspase-induced Apoptosis. HDAC4-IN-1 has anticancer activity. HDAC4-IN-1 can be used in the research of drug combination against cancer[1].
CAS Number
1418293-39-6
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac4-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCN(CC)CC)C1=CC=C(C2=NOC(C(F)(F)F)=N2)C=C1
Molecular Formula
C16H19F3N4O2
Molecular Weight
356.34
References & Citations
[1]Asfaha Y, et al. 5- (Trifluoromethyl) -1,2,4-oxadiazole (TFMO) -based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib. Eur J Med Chem. 2023 Nov 10;263:115907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2; HDAC4; HDAC6; HDAC8

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