Products for Research Use Only
RegisterLogin

BTK ligand 1

CAT: 0804-HY-150885Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-150885Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk) . BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].
CAS Number
330785-90-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Btk; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-ligand-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCNCC5
Molecular Formula
C22H22N6O
Molecular Weight
386.45
Precautions
H315, H319, H320
References & Citations
[1]Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57 (26) :3564-3575.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-49421-01BTK ligand 12
HY-173126BTK ligand-14
HY-168314-01BTK ligand 11
HY-179076BTK/IKZF1/3 ligand 1
HY-175543BTK ligand 16
HY-168965BTK ligand 15
HY-168292BTK ligand 9
HY-168302BTK ligand 10
HY-101941-01BTK IN-1
HY-176381BTK ligand 11-alcohol-PEG6-azido

Alternative Products

CatalogName
F4600-07-01Flt3 Ligand (Fms-like Tyrosine Kinase 3 Ligand, flk2 Ligand)
GTR19010225-01CD40 ligand
cyt-340-01mFlt3 Ligand
400305-01Flt3 ligand
522887-01FAS Ligand
MBS7042993-01Kit ligand
GTR19020256-01ICOS ligand
cyt-1041-01pFlt3 Ligand

Popular Products