PARP1-IN-12
CAT:
804-HY-150765
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PARP1-IN-12
- UNSPSC Description: PARP1-IN-12 is a potent PARP1 inhibitor with an IC50 of 2.99 nM. PARP1-IN-12 exhibits antiproliferative activity, can induce cell apoptosis and cause cycle arrest at G2/M phase. PARP1-IN-12 also can induce DNA double strand breaks (DSBs) in BRCA-deficient cells[1].
- Target Antigen: Apoptosis; PARP
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/parp1-in-12.html
- Solubility: 10 mM in DMSO
- Smiles: FC1=CC=C(CC(C2C=CC=CC23)=NNC3=O)C=C1C(N4CCN(CC4)C(CCCCCCCNCC5C(OC6C5C=C7[C@@](C)(C6)CCC[C@@H]7C)=O)=O)=O
- Molecular Weight: 741.93
- References & Citations: [1]Kayumov M, et al. Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone. Eur J Med Chem. 2022 Jun 28;240:114574.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported