PARP1-IN-16
CAT:
804-HY-156298
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PARP1-IN-16
- UNSPSC Description: PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor, with an IC50 of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells[1].
- Target Antigen: Apoptosis; PARP
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/parp1-in-16.html
- Solubility: 10 mM in DMSO
- Smiles: FC(C=CC(CC1=NNC(C2=CC=CC=C21)=O)=C3)=C3C(N4CCN(CC4)C(CCCO/N=C5/C(NC6=CC=CC=C65)=C7C8=C(NC\7=O)C=CC=C8)=O)=O
- Molecular Weight: 711.74
- References & Citations: [1]Wan S, et, al. Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer. Eur J Med Chem. 2023 Oct 6:261:115843.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported