ERK5-IN-4

• UNSPSC Description:

  ERK5-IN-4 (compound 34b) is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). ERK5-IN-4 inhibits ERK5 (full-length) and truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with an IC50 of 77 nM and 300 nM, respectively[1].

• Target Antigen:

  ERK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erk5-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(C(C2=C(Cl)C=CC(Cl)=C2F)=O)=CN1)NC3=CN(C)N=C3

• Molecular Weight:

  381.19

• References & Citations:

  [1]Miller DC, et al. Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. J Med Chem. 2022 May 12. 65(9):6513-6540.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1888305-17-6