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CYP3A4-IN-2

CAT: 0804-HY-150580Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150580Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants[1].
CAS Number
2562383-94-0
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cyp3a4-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)NC(CC1=C2C=CC=CC2=CC=C1)CSCC(NC3=CC=CC=C3)C(NCC4=CC=CN=C4)=O
Molecular Formula
C33H38N4O3S
Molecular Weight
570.74
References & Citations
[1]Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28 (6) :115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3

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