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SMS2-IN-3

CAT: 0804-HY-150559Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150559Size:1 Each
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Description
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels[1].
CAS Number
2414240-89-2
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Others
Assay Protocol
https://www.medchemexpress.com/sms2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
Molecular Formula
C33H39F3N4O6
Molecular Weight
644.68
References & Citations
[1]Takafumi Yukawa, et al. Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem. 2020 Apr 1;28 (7) :115376.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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RPD83828-01SMS2-IN-2
T12938-01SMS2-IN-1
sc-293384SMS2 (7D10)
A19568-50SMS2-IN-2 50mg
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A19568-25SMS2-IN-2 25mg
A19568-10SMS2-IN-2 10mg

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